Drs. Pravin Khemani and Michael Elliot from Swedish Neuroscience Institute in Seattle, Washington, published a case study last month in Parkinsonism and Related Disorders that highlights the role of the Syn-One Test in distinguishing overlapping clinical phenotypes of synucleinopathies from non-synucleinopathies.
Medical Laboratory Professionals Week is celebrated each year during the last week of April “…to recognize laboratory professionals for their valuable contributions directly impacting clinical and public health,” according to the CDC.
The methodology behind the Synuclein-One Study, the largest study to date of cutaneous phosphorylated alpha-synuclein detection, was published this month in Biomarkers in Medicine by CND Life Sciences’ senior scientific advisors Dr. Christopher Gibbons and Dr. Roy Freeman and members of CND’s scientific team, Todd Levine, MD and Bailey Bellaire.
CND Life Sciences is pleased to announce the next webinar in our Tuesday Night Talks series. Todd Levine, MD, CND’s Co-Founder and Chief Medical Officer
welcomes special guest Stuart H. Isaacson, MD, FAAN, Director of the Parkinson’s Disease and Movement Disorders Center of Boca Raton, FL to discuss the role and importance of alpha-synuclein as a key
pathological marker.
More than 300 million people, or 5% of the worldwide population, are living with a rare disease, defined as a disease that affects fewer than 200,000 people at any given time. Those with rare diseases are often misdiagnosed or not diagnosed at all, which makes it nearly impossible to find the right care.
Most neurodegenerative disorders are linked to some form of protein misfolding, which results in accumulation of the protein, neuronal dysfunction, and eventually cell death.
Arriving at a definitive diagnosis of any given neurodegenerative condition is not always easy. Recent studies have shown that even in the hands of the best movement disorder specialists, patients diagnosed
with Parkinson’s disease who come to autopsy show no evidence of Lewy bodies and have an alternate diagnosis 30% of the time. Similar data exist for patients with multiple sclerosis, Alzheimer’s disease, and immune-mediated neuropathies. These data tell us that clinical diagnostic skills and tests cannot always accurately distinguish the varied forms of neurodegenerative diseases.
A core value at CND Life Sciences is being clinician-minded. We are founded by practicing neurologists and we are dedicated to helping clinicians care for patients facing a possible diagnosis of a neurodegenerative disease. While the biopsy procedure is straight-forward, we understand that not all neurologists have performed skin biopsies.
In CND Life Sciences’ newest case study, Dr. Todd Levine describes the case of a 64-year-old woman with a long history of multiple sclerosis. She had tried several treatments over the previous three decades with varying degrees of success and exhibited a classic relapsing-remitting disease course.
Dr. Todd Levine, CND Life Sciences’ Co-Founder and CMO, will speak at the product presentation theater at the American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) annual meeting this month. His talk, “In-Office Cutaneous Testing for Pure Autonomic Failure and Other Synucleinopathies: Introducing the Syn-One Test™,” will be held Friday, October 15 at 3:40 pm MST.
© CND Life Sciences | Diagnostic Insights for Life™ | All rights reserved. | Notice of Privacy Practices | Machine-readable Files
Dr. Thompson joined CND Life Sciences as Senior Dermatopathologist in March 2023 and brings 23 years of post-graduate medical experience, including residency training in anatomical and clinical pathology; a chief residency; and fellowships in surgical pathology, cytopathology, and dermatopathology at UCLA. Dr. Thompson is responsible for interpretation of phosphorylated alpha-synuclein slides, assisting in the optimization of the H&E portion of the Syn-One Test®, and collaborative efforts to develop additional cutaneous neurodiagnostic assays.
Dr. Thompson was a private practice dermatopathologist and then joined Wayne State University School of Medicine in Detroit, MI as an Assistant Professor of Pathology. During his tenure at Wayne State University, authored numerous articles, including two review articles of molecular studies in malignant melanoma, and won the Excellence in Teaching Award in Anatomic Pathology in 2017. In 2019, Dr. Thompson joined West Virginia University School of Medicine in Morgantown, WV as an Associate Professor of Pathology. There he continued to sign-out a diverse array of dermatopathology cases, including specimens from the dermatology department, skin immunofluorescence, and larger surgical resections of cutaneous malignancies, including metastases to lymph nodes and other anatomic sites.
His undergraduate degree is from Stanford University, where he was chosen for Phi Beta Kappa. He then attended UCLA Medical School and earned a combined MD and PhD in molecular biology via the Medical Scientist Training Program. He is a fellow of the American Society of Dermatopathology, the College of American Pathologists, and the American Society for Clinical Pathology.
Mackenzie joined CND Life Sciences as Senior Manager, Clinical Services in March 2021. In her role, Mackenzie provides personalized support to both clinicians and patients, drives the development of new programs and processes to ensure customer satisfaction, and works closely with the laboratory and other departments to establish cross functional success. Mackenzie studied Biomedical Engineering at the University of Arizona and received her Master of Engineering in Bioengineering at the University of California, Berkeley. Prior to joining the team, Mackenzie managed over 100 neuroscience clinical research trials at HonorHealth Research Institute and was a key player in the development and management of their COVID-19 clinical research program. Mackenzie has also spent time in academic research studying Alzheimer’s disease at Fred Hutchinson Cancer Research Center. Personally impacted by the devastating reality of neurodegenerative diseases, Mackenzie has a passion for patient care and support.
Dave joined CND Life Sciences as SVP, Finance & Strategy in early 2022, and brings 15 years of healthcare, finance, and consulting experience. In his role at CND, Dave leads a range of finance and accounting activities, corporate development efforts, and strategic initiatives, including the evolution and management of the company’s Clinical Trials Services solutions for biopharma clients. Prior to joining CND, Dave worked on commercial assessments of neuroscience business development opportunities as well as various strategic initiatives at AbbVie. Dave also worked at J.P. Morgan in the Healthcare Investment Banking Group, where he provided financial and strategic advisory services for M&A and equity and debt transactions for pharmaceutical, biotechnology, healthcare services, and healthcare IT companies. Dave received his MBA from the Kellogg School of Management at Northwestern University and his BA from the University of Michigan. Dave and his wife like to sail, ski, and hike with their dog in their free time.
Alex joined CND Life Sciences as the Director of IT in late 2022 to lead a range of technology areas and initiatives for the company, including cybersecurity, digital pathology infrastructure, and employee enablement. He has been a part of large IT organizations for more than a decade and brings a health sciences background from a collaboration between the University of Utah Department of Pathology and Associated Regional and University Pathologists (ARUP). Alex’s experience in previous positions has allowed him to develop a hybrid technical- and leadership-driven approach to his work.
Jennifer started working with CND Life Sciences in early 2020 as Creative Director and Principal of a boutique branding and creative design firm, Juniper Hill Creative, before officially joining CND in early 2023 as Director of Brand Marketing. Jennifer brings decades of experience and expertise in marketing experiences, brand identity, and web design in the life science industry.
Prior to Juniper Hill, Jennifer was SVP of Creative and Production Services at Aptus Health, a former subsidiary of Merck, Inc. (acquired by WebMD) and Creative Director at RxCentric, an innovative digital marketing company focused on interactive programs for healthcare professionals. Before turning her focus to healthcare, Jennifer spent several years in the entertainment industry creating immersive user experiences, interactive sports and television applications, and 3D entertainment software for top ecommerce retailers. Jennifer is a recipient of multiple industry awards, including Hermes, Webby, Davey, WebAwards, and an Interactive Academy Award for a documentary on the Titanic.
Jennifer graduated from California State University Fullerton with a Bachelor of Arts degree in Communications.
Sara joined CND Life Sciences as Financial Controller in June 2022 and brings a decade of diverse accounting experience, ranging from external assurance services to internal accounting at both privately held and publicly traded entities. In addition to leading the accounting team, Sara supports strategic financial initiatives throughout the organization and enjoys working with functional leaders on establishing processes and creating efficiencies.
Prior to joining CND, Sara provided client accounting services at a start-up cloud-based accounting firm, where she led multiple industry vertical service teams and mentored team members through an internal coaching program. Sara is a CPA and received both her Bachelor of Science and Master of Accountancy from the W.P. Carey School of Business at Arizona State University.
Cherry joined CND Life Sciences as VP, Revenue Cycle Management in April of 2023 reporting into the Finance and Strategy function of the company. She brings over 30 years of revenue cycle management experience across multiple specialties within the healthcare industry. Her focus has centered around employee development and establishing best-in-class billing practices. Prior to joining CND, Cherry worked for several large organizations spearheading expansion, centralizing billing operations, and establishing high performing teams focused on exceeding financial and operational expectations.
Cherry holds a Master of Science in Leadership and a Doctorate in Organizational Leadership with an emphasis in Health Care Administration from Grand Canyon University in Phoenix. She earned her Bachelor of Science in Accounting and Finance from Argosy University in Phoenix.
Dr. Gibbons, one of CND Life Sciences’ three founders and a senior scientific advisor, has played an integral role in translating key science in the field to help develop the company’s core diagnostic technology. Dr. Gibbons is a clinician-scientist involved in the investigation, evaluation, and treatment of patients with autonomic and peripheral nerve disorders. Dr. Gibbons’ clinical expertise extends to the investigation and treatment of autonomic and peripheral neuropathies. He has served as Chair of the Clinical Affairs Committee for the American Autonomic Society, and Chair of the Autonomic Section of the American Academy of Neurology, President of the American Autonomic Society and is currently Chair of the International Diabetes Neuropathy Consortium. Dr. Gibbons has established the neurocutaneous skin biopsy lab at Beth Israel Deaconess Medical Center (BIDMC), where he oversees all clinical testing. He has also received several grants to study cutaneous α-synuclein expression in nerves within the skin.
Dr. Gibbons attended Dartmouth College, completed his medical training at Albert Einstein College of Medicine and his residency in Neurology at Johns Hopkins Hospital. Dr. Gibbons also received a Master in Medical Science degree through a combined Harvard and MIT training program. Dr. Gibbons is an Associate Professor of Neurology at Harvard Medical School and on staff at BIDMC and Joslin Diabetes Center in Boston, Massachusetts.
Dee joined CND Life Sciences as an HR contractor in March of 2022 and came on permanently as Director of HR in June. She brings 15 years of experience across a variety of industries, with a focus on small- to medium-sized businesses. In her role at CND, Dee leads the HR department in all its functions, ranging from administrative responsibilities to strategic business partnerships with the organization’s senior leaders. Prior to joining CND, Dee worked as an HR professional at a start-up cloud-based accounting firm. Dee received her Master of Science in Management with a concentration in Leadership and Organizational Effectiveness from the University of South Florida and her BA in Communications from Jacksonville University.
Dr. Roy Freeman, one of CND Life Sciences’ three founders and a senior scientific advisor, is Professor of Neurology at Harvard Medical School and director of the Center for Autonomic and Peripheral Nerve Disorders in the Department of Neurology at Beth Israel Deaconess Medical Center in Boston, Massachusetts. Dr. Freeman is former chairman of the World Federation of Neurology research group on the autonomic nervous system, former president of the American Autonomic Society, and former chairman of the Autonomic Section of the American Academy of Neurology. He serves on the Executive Committee and the Steering Committee of the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION), a public-private partnership with the FDA. His research and clinical interests are the physiology and pathophysiology of the small nerve fibers and the autonomic nervous system. He has a special interest in biomarker development in neurodegenerative disease. He is the principal investigator on National Institutes of Health-funded studies on the neurological complications of diabetes, the neurobiology of stress, and biomarker development in alpha-synucleinopathies. He is Editor-in-Chief of Autonomic Neuroscience: Basic and Clinical and on the editorial boards of The Clinical Journal of Pain, Pain: Clinical Updates, and Clinical Autonomic Research.
Dr. Paler joined CND Life Sciences in July 2022 as Chief Pathologist and Laboratory Medical Director, responsible for leading the Pathology department, performing slide interpretation in support of the Syn-One Test® and other cutaneous neurodiagnostic tools, and ensuring CND meets and exceeds all laboratory quality standards. Dr. Paler is also a key contributor to CND’s research and development projects, continuous improvement initiatives, and collaborations with the biopharma industry. An anatomic and cytopathology board-certified pathologist, he attended Wayne State University School of Medicine in Detroit, MI and performed residency training at Los Angeles County + USC Medical Center in Los Angeles. He has practiced pathology in the commercial reference laboratory setting for 22 years. Prior to starting at CND, he worked as Medical Director and Surgical Pathologist at Labcorp Oncology (formerly Impath and Genzyme Genetics) for 21 years, the last eight years as Medical Director in Phoenix, AZ. His accomplishments include verification and implementation of PD-L1 companion diagnostic testing, HPV mRNA ISH testing, digital pathology, novel IHC markers, EGFR, KRAS, and NRAS molecular testing, and the launch of new LIS systems. He has served on various committees within the College of American Pathologists, including the 15189 Committee and the CAP Personalized Healthcare Committee. He is a member of the College of American Pathologists, American Society for Clinical Pathology, United States and Canadian Academy of Pathology, and the American Medical Association. Dr. Paler is an ardent champion of laboratory quality and ISO 15189 principles, and he advocates as a leader in Diversity, Equity, and Inclusion initiatives.
Dr. Feng joined CND Life Sciences in November 2021 as a Senior Pathologist and Laboratory Medical Director, responsible for performing slide interpretation in support of the Syn-One Test™ and other cutaneous neurodiagnostic tools and ensuring CND meets and exceeds all laboratory quality standards. Dr. Feng is also a key contributor to CND’s research and development projects, continuous improvement initiatives, and future collaborations with the biopharma industry. An anatomic and clinical board-certified pathologist, she attended NYU School of Medicine and performed residency training at the University of Arizona. She has practiced pathology in both private and academic settings. Prior to starting at CND, she worked as a pathologist at Roche Tissue Diagnostics (formerly Ventana Medical Systems) for 17 years. Her accomplishments include developing a companion immune-oncology biomarker for hepatocellular carcinoma and developing biomarkers for HER2 in new tumor indications with high unmet medical needs such as biliary tract carcinomas, colorectal cancer, and NSCLC. For the past three years, she also served as the medical director for the CAP/CLIA Laboratory at Roche, overseeing more than 200 clinical trials sponsored by a variety of pharmaceutical companies. During her tenure as medical director, the laboratory maintained its accreditation by the College of American Pathologists and acquired accreditation by ISO 15189 and the New York State Department of Health.
Dr. Haydel joined CND Life Sciences in November 2021 as a Senior Pathologist in the company’s pathology services group. In her role with CND, Dr. Haydel performs histologic interpretation of bright field and fluorescent slides and images for patient diagnosis and categorization in support of the Syn-One Test™ and other cutaneous neurodiagnostic tools offered by CND. In addition, Dr. Haydel is a key contributor to CND’s pathology optimization efforts, ongoing scientific and innovation programs, and a range of research initiatives. She is a board-certified pathologist with both anatomic and clinical specialty training from UC Irvine and has dual subspecialty fellowship training in pediatric pathology from Children’s Hospital Los Angeles and in dermatopathology from UCLA. She has a special interest in genetics as it relates to inherited and epigenetic mechanisms of acquiring disease, including disease identification and pharmacologic intervention. She earned a Master’s of Science in Human Genetics from Tulane University and has worked in both academic and private practice settings.
Jade joined CND Life Sciences in November 2020 and brings a decade of experience in clinical research, predominantly in the neuroscience field. In her role, she oversees NIH-sponsored clinical studies by supporting the principal investigators, recruiting and enrolling subjects, and onboarding sites for participation. She is currently focusing on two NIH-SBIR-awarded grants, one of which is a validation study involving 500 subjects at 28 sites around the US. Prior to joining CND, Jade worked at Barrow Neurological Institute and Honor Health, with a focus on neurological research.
Dr. Enrique Carrazana has over 25 years of experience in drug development and the pharmaceutical industry. In addition to CND Life Sciences, Dr. Carrazana is on the board of directors of Hawaii Biotech and the American Society for Experimental Neurotherapeutics. He currently serves as the Chief Medical Officer for Neurelis, Inc., where he is responsible for the management of the drug development and safety programs. Previously, he was the Chief Medical Officer of Acorda Therapeutics. Dr. Carrazana also held various medical leadership roles at Novartis, where his last role was Vice President, Global Head Development Established Medicines Franchise, based in Basel, Switzerland. He was Director of the Epilepsy Center of Excellence at the Miami Veterans Administration Hospital and Associate Professor of Neurology at the University of Miami Miller School of Medicine. He has presented and published a wide range of research on various neurology topics. Dr. Carrazana received his medical degree from Harvard Medical School and completed his residency in neurology and fellowship in neurophysiology at the Harvard Longwood Neurology Program. He is a board-certified neurologist and Fellow of the American Epilepsy Society.
Peter has over 25 years of experience in the life sciences industry as an entrepreneur, business owner-operator, and investor. Prior to his involvement with CND Life Sciences, Peter was owner and CEO of B&V Testing, Inc., an industry-leading life sciences engineering services firm focused on contamination control technologies and serving the east coast’s premiere pharmaceutical, medical device, and biomedical research institutions. While at B&V, Peter pioneered the commercial application of hydrogen peroxide vapor technology for large-scale decontamination of cGMP pharmaceutical manufacturing facilities. A graduate of Duke University, Peter was a regular presenter at the annual biosafety conference of the American Biological Safety Association and the annual technical conference of the Controlled Environment Testing Association. His tenure at B&V culminated with a strategic sale to Stericycle, Inc. (NASDAQ: SRCL) in 2013. Since that time, he has been an active investor in mission-driven businesses. He lives in Brookline, MA with his wife and three children where he can be found coaching youth sports and serving as a volunteer mentor to aspiring business owners.
Dr. Levine is one of the three founders of CND Life Sciences and serves as its Chief Medical Officer, playing a key role in the delivery of diagnostic services and ongoing technology development. Dr. Levine also serves as the Medical Director of HonorHealth Neurology and has over 20 years of experience as a clinical neurologist with a sub-specialty in disorders of the peripheral nervous system. In 2010, he founded his first medical diagnostics company called Corinthian Reference Lab (CRL). CRL is based in Fort Worth, Texas and has processed over 50,000 skin biopsies, receiving specimens from over 4,000 different neurologists across the US and Canada. He received his medical degree from Duke University and did his residency and fellowship at Washington University in St Louis. He has served as the Chairman of the Neuromuscular Division of the American Academy of Neurology and is currently the Medical Director of Neurology for HonorHealth in Phoenix, AZ.
Andy is currently an active entrepreneur and Angel Investor with portfolio holdings in life sciences, software, e-learning, advanced manufacturing, AI, and real estate tech. He is currently an Entrepreneur-in-Residence at IESE Business School in Barcelona, where he mentors and advises a variety of entrepreneurs and start-ups. He is the founder of Component Sourcing International LLC (CSI), a Strategic Sourcing™ company that manufactures custom-engineered metal components in a variety of product categories. The company was acquired by a private equity firm in 2014.
Prior to founding CSI, Andy was a Partner in Osage Investments, a private equity firm based in Philadelphia, with funds dedicated to leveraged buyouts of middle-market manufacturers and early-stage venture investing. Andy held various board and management positions in Osage’s portfolio, and his venture investments include Inphonic (NASDAQ: INPC), Internet Capital Group (NASDAQ: ICGE), and GHR Systems (acquired by Metavante). He also served as CEO of Farmington Engineering, an Osage portfolio company later acquired by Swiss conglomerate KVT Group.
Andy holds a BS in Biology from Tufts University and an MBA in Finance and Entrepreneurial Management from the Wharton School, University of Pennsylvania. His current passion is social impact investing, and he just recently returned from two years in in Barcelona, Catalunya, Spain to reside in Connecticut with his family.
Rick joined CND Life Sciences as CEO in early 2020 and brings 25 years of experience with health and life sciences companies, serving in senior executive roles globally for medical device, digital health, and diagnostics firms. Prior to joining CND as CEO, Rick was the Global President of Life Sciences at Aptus Health, a former subsidiary of Merck, Inc. (acquired by WebMD) and CEO of Plasma Surgical, an innovative medical device company with technology used in open and laparoscopic procedures around the world. Rick began his career in strategy consulting, rising to Partner at Mercer Management Consulting where he helped build the Health & Life Sciences Practice and managed large biopharma and diagnostics clients. A Kellogg MBA and graduate of the University of Virginia, Rick also founded and helped grow three nonprofit organizations that have raised nearly $100 million in the last decade to fulfill health and social impact missions including Family Reach Foundation, which was included in the Obama White House’s Cancer Moonshot in 2016.
Bailey joined CND Life Sciences in 2018 as one of the first full-time employees of the organization. In his current role as Manager, Research & Development, Bailey focuses on conducting laboratory process improvement, test optimization, exploratory research, and new product development. His team also supports the execution of Syn-One testing protocols as part of company- and grant-funded clinical studies and industry-sponsored trials involving drug candidates that target alpha-synuclein or related mechanisms of action. As a biomedical engineering graduate of the University of Arizona, Bailey brings foundational science and research capabilities to CND along with an understanding of pharmaceutical, organic chemistry, and personalized medicine disciplines.
Karina serves as CND Life Sciences’ Director of Billing Services and Operations, playing an integral role in establishing the company’s billing and reimbursement protocols, policies, and infrastructure in support of commercializing the Syn-One Test™. In addition to overseeing CND’s revenue cycle management processes, which include daily interactions with public and private payers, Karina conducts important prior-authorization and patient support services critical to offering the Syn-One Test as a new diagnostic tool in clinical practice. Karina joined CND Life Sciences in 2019 and helped implement the company’s laboratory infrastructure, quality standards, day-to-day processes, and CLIA certification. Prior to joining CND, Karina spent over a decade with other prominent laboratory companies, including Genzyme Genetics, LabCorp, and Agendia, where she successfully managed a large staff and assisted in laboratory set up, accreditation, and optimization. Karina received her bachelor’s degree in Public Health and Bio-Education from the University of California at Long Beach.
Jimmie joined CND Life Sciences in 2021 as the Laboratory Director, where he is responsible for managing, enhancing, and monitoring operational systems for the laboratory’s production, quality, staff development, and day-to-day specimen processing functions. In this important leadership role, Jimmie utilizes his training as a laboratory inspector to develop the Quality Assurance Plan for daily operations to ensure the highest quality test results. He has over 20 years of experience managing College of American Pathologist (CAP)-accredited laboratories and has worked for several large healthcare systems. Jimmie became a certified CAP inspector in 2017 and has conducted on-site laboratory inspections as a team member and as a team lead. Prior to joining CND, Jimmie spent decades working with prominent healthcare organizations including the American Red Cross, Sutter Health, Emory Healthcare, and United Blood Services. Jimmie attended the University of Arizona and received his Bachelor of Science degree in Clinical Laboratory Sciences from the University of Texas Health Science Center in San Antonio, Texas.
