The co-occurrence of peripheral neuropathy and parkinsonism is more common than previously understood. A recent publication in in Movement Disorders Clinical Practice reviews current evidence exploring how peripheral nerve involvement may be observed in some individuals with Parkinson’s disease and related conditions.1
The authors describe how symptoms related to peripheral neuropathy can overlap with those commonly seen in parkinsonism, which may make recognition challenging in routine clinical settings. The review discusses a range of possible drivers of peripheral nerve changes, including disease-related factors, nutritional considerations, metabolic conditions, and medication exposure, including levodopa.
The publication also notes that peripheral neuropathy, when present, may be associated with functional concerns such as changes in sensation or balance. Non-motor symptoms of parkinsonism, including sensory changes such as pain and symptoms of autonomic dysfunction such as temperature dysregulation are examples of symptoms that may overlap with symptoms related to peripheral neuropathy. Motor symptoms of weakness and gait disturbance or falls may also be present in patients with either condition. Recognizing these features may provide additional context during clinical evaluation and support a more comprehensive understanding of a patient’s neurological profile.
This review highlights the complexity of neurological symptoms in parkinsonism and emphasizes the value of considering both central and peripheral nervous system involvement when interpreting clinical findings.
References
1Moreno-Lopez C, Antenucci P, Moura J, Bhatia KP. Unraveling Peripheral Neuropathy in Parkinsonism from Acquired to Genetic Forms: A Review with Diagnostic Framework for Clinicians. Mov Disord Clin Pract. 2026 Jan 6. doi: 10.1002/mdc3.70503. Epub ahead of print. PMID: 41492790.
