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On Our Radar

Researchers Discover How Alpha-Synuclein May Form Toxic Aggregates

By On Our Radar

Lipids are thought to play an important role in the aggregation of alpha-synuclein and are found in Lewy bodies, the hallmark of Parkinson’s disease. Research to date on the molecular interaction between lipids and alpha-synuclein—utilizing experimental methods such as nuclear magnetic resonance, electron paramagnetic resonance, and neutron reflectivity—has mostly been carried out at relatively low concentrations of alpha-synuclein.

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