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Can You Name the Five Synucleinopathies?

By January 27, 2022October 3rd, 2023No Comments

Can You Name the Five Synucleinopathies?

Most neurodegenerative disorders are linked to some form of protein misfolding, which results in accumulation of the protein, neuronal dysfunction, and eventually cell death.

Two common examples:

  • Parkinson’s disease, with the misfolded alpha-synuclein protein
  • Alzheimer’s disease, with the misfolded tau protein

There are 5 distinct disorders characterized by the deposition of phosphorylated alpha-synuclein:

  • Parkinson’s disease (PD)
  • Dementia with Lewy bodies (DLB)
  • Multiple system atrophy (MSA)
  • Pure autonomic failure (PAF)
  • REM sleep behavior disorder (RBD)

All synucleinopathies are characterized by the deposition of the pathological protein— phosphorylated α-synuclein—in the central and/or peripheral nervous systems, resulting in progressive neurological degeneration.

There are over 2 million people in the United States who have been diagnosed with a synucleinopathy, with 100,000 new diagnoses each year. The annual healthcare costs in the US attributable to synucleinopathies are estimated in the tens of billions of dollars.