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Potential Parkinson’s Treatment Well-Tolerated in Phase 1 Trial

By November 16, 2022August 7th, 2024No Comments

Potential Parkinson’s Treatment Well-Tolerated in Phase 1 Trial

1ST Biotherapeutics, Inc., announced positive results from a Phase 1 trial of FB-101, an investigational compound being studied to treat Parkinson’s disease and other neurodegenerative disorders. FB-101 inhibits c-Abl (Abelson tyrosine kinase), a protein that plays a role in the toxic buildup of alpha-synuclein.

The randomized, double-blind, placebo-controlled study was conducted in 24 healthy subjects and assessed the safety, tolerability, and pharmacokinetic profile of a single ascending oral dose of FB-101. The compound was well-tolerated and showed no significant safety signals. FB-101 effectively crossed the blood-brain barrier as measured by subjects’ cerebrospinal fluid.

1ST Biotherapeutics plans to move FB-101 into a multiple ascending dose trial by the end of 2022. The results from that study will be used to determine the correct dose for evaluating the efficacy and safety of FB-101 in patients with Parkinson’s. 1ST Biotherapeutics will also begin clinical testing of FB418, which inhibits both c-Abl and LRRK2, as a potential treatment for Parkinson’s disease early next year.

Read about the trial

CND Life Sciences

CND Life Sciences is the creator of the Syn-One Test, the world’s first commercially available test to visualize phosphorylated alpha-synuclein in cutaneous nerve fibers. The test is an objective, evidence-based diagnostic tool to aid in the diagnosis of Parkinson’s disease, dementia with Lewy bodies, multiple system atrophy, or pure autonomic failure.