Patient Information Guide

Your healthcare provider has recommended the Syn-One Test® or Small-Fiber Dx® as part of your care. CND Life Sciences is here to support you through the process and ensure you have all the information you need.

The Syn-One Test is a simple and convenient way to help detect the abnormal form of the synuclein protein that is common to neurological disorders such as Parkinson’s disease, dementia with Lewy bodies, and other related conditions. With the test results, you and your healthcare provider can better understand your health and help guide the best next steps for your care.

The Small-Fiber Dx test is a simple and convenient way to measure the number of small nerve fibers in the skin, or intraepideramal nerve fiber density (IENFD), to confirm a diagnosis of small fiber neuropathy. With the test results, you and your healthcare provider can better understand your health and help guide the best next steps for your care.

What to Expect
The test involves a skin biopsy procedure performed in a health care provider’s office, which typically takes about 15 minutes. During the procedure, three small samples are taken from your skin. No stitches are needed, and it heals like a small scab.

Insurance and Coverage Review
Insurance can be complicated. We are here to help you understand your benefits, costs, and next steps.

What happens first
Your healthcare provider sends a completed benefit verification form and supporting documentation to CND. This allows us to check your insurance benefits.

What CND does for you

Contact your primary health insurance to verify insurance coverage details
Determine applicable copay, coinsurance, and deductible amounts that apply to your plan
Confirm how much your insurance is likely to cover, including any limitations
Provide an estimated out-of-pocket (OOP) cost, so you know what to expect

How we keep you updated

CND may call or text you during the benefits verification process
Look for calls from a 480-area code and check your voicemail for updates

Patient Assistance Program
If your insurance does not cover the full cost, or if you do not have insurance, CND may be able to help. Our Patient Assistance Program provides discount pricing, flexible payment plans, and CareCredit® options based on your financial situation. If you are uninsured, or if your out-of-pocket cost is more than you can afford, please contact us to review your options.

Patient Care Alerts (Optional)
Opt-in to receive real-time text messages about your benefits and updates on:

Your estimated out-of-pocket (OOP) costs
Follow-ups on scheduling your biopsy procedure

How it works:

You’ll receive an enrollment text message from CND
Verify your phone number
Confirm your last name and date of birth as listed on your insurance plan
We’ll text when your benefits check is complete
Our support team can help you with next steps, such as:

Scheduling your biopsy appointment
Making a pre-payment
Discussing financial options

You can expect 2 to 4 texts depending on your situation and can opt out at any time.

Every Patient’s Situation is Unique
Below is an overview of the benefits verification process. Your experience may vary based on your insurance plan and personal circumstances.

Benefits Verification Request Submitted
Your provider’s office submits benefits verification form and supporting documents

Account Enrollment for Text Updates
Opt-in to receive an enrollment text message and verify your information

Insurance & Coverage Review
CND verifies insurance coverage and calculates estimated out-of-pocket cost

Prior Authorization if Required by Insurance
CND will attempt to initiate authorization from your insurance company

Benefits Verification Complete
You and your provider’s office receive estimates out-of-pocket cost

Schedule Your Test
Contact your provider’s office to schedule biopsy procedure

Preparing for Your Skin Biopsy Procedure
To avoid any delays, please call your healthcare provider’s office to schedule your biopsy appointment as soon as you are ready. Some healthcare providers may have special instructions, so be sure to check with your provider before the procedure. Below you will find some common expectations and helpful tips to prepare.

What to Expect During the Procedure

The skin biopsy procedure takes approximately 15 minutes
Samples are taken from three locations: the back of your neck, just above your knee, and just above your ankle
Areas are numbed with a local anesthetic, like lidocaine, that stings for about 10 seconds, then allows the biopsies to be done with minimal discomfort
A small instrument is used to collect the samples
No antibiotics or stitches are needed
Keep the area dry for 24 hours. Bandages should stay on for 48 hours
The sites will form small scabs that gradually heal and fade over time

Tips for Procedure Day

Wear loose-fitting clothing for comfort and ease of access to the biopsy areas
After the procedure, you will receive written post-biopsy care instructions
Your healthcare provider will receive the results in about 3 weeks; however, this timeline may vary
If you have any questions, consult your healthcare provider’s office and they will guide your care

Our team is here to answer your questions, keep you informed, and support you every step of the way.

CND Life Sciences
9165 E Del Camino Dr, Suite 101, Scottsdale, AZ 85258
480.569.2900
cndlifesciences.com