At the 2021 American Academy of Neurology meeting last month, Dr Alexandru Barboi and colleagues presented their observations on the use of the Syn-One Test™ in the evaluation of patients with autonomic symptoms.

Over a 6-month period, they evaluated 18 patients with autonomic symptoms with laboratory, electromyographic, and autonomic reflex testing. In addition, each patient was evaluated with the Syn-One Test to detect the presence of phosphorylated alpha-synuclein (p-syn), determine the intraepidermal nerve fiber density, and detect the presence of amyloid.

Fifteen of the eighteen cases had abnormal p-syn deposition. Post-biopsy diagnoses included pure autonomic failure (n=8), Lewy body dementia (n=3), multiple system atrophy (n=2), and Parkinson’s disease (n=2). Three of the eighteen cases showed no p-syn deposition, and after extensive evaluation, it was concluded that one patient had autonomic dysfunction on the basis of diabetic autonomic neuropathy, one had distal inflammatory demyelinating neuropathy, and one had sensory ganglionopathy from Sjogren’s syndrome.

The authors conclude that the Syn-One Test is a useful tool for the evaluation of patients presenting with autonomic symptoms.

Read the abstract at https://index.mirasmart.com/AAN2021/PDFfiles/AAN2021-002534.html