SCIENTIFIC PUBLICATIONS
Antelmi E, Donadio V, Incensi A, Plazzi G, Liguori R. Skin nerve phosphorylated α-synuclein deposits in idiopathic REM sleep behavior disorder. Neurology. 2017;88(22):2128-2131. doi:10.1212/WNL.0000000000003989
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Beach TG, Adler CH. Importance of low diagnostic accuracy for early Parkinson’s disease. Mov Disord 2018;33(10):1551-1554. doi: 10.1002/mds.27485
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Boruchow SA, Gibbons CH. Utility of skin biopsy in management of small fiber neuropathy. Muscle Nerve 2013;48(6):877-882. doi: 10.1002/mus.23859
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Cassard L, Honari G, and Tousi, B, The skin and Lewy body disease. J Alzheimers Dis. 2024;100(3):761-769. doi: 10.3233/JAD-240198
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Devigili G, Rinaldo S, Lombardi R, et al. Diagnostic criteria for small fibre neuropathy in clinical practice and research. Brain. 2019;142(12):3728-3736. doi:10.1093/brain/awz333
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Donadio V. Skin nerve α-synuclein deposits in Parkinson’s disease and other synucleinopathies: a review. Clin Auton Res.2019;29(6):577-585. doi:10.1007/s10286-018-0581-4
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Donadio V, Doppler K, Incensi A, et al. Abnormal α-synuclein deposits in skin nerves: intra-and inter-laboratory reproducibility. Eur J Neurol.2019;26(10):1245-1251. doi:10.1111/ene.13939
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Donadio V, Incensi A, El-Agnaf O, et al. Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study. Sci Rep.2018;8(1):14246. doi:10.1038/s41598-018-32588-8
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Donadio V, Incensi A, Rizzo G, et al. A new potential biomarker for dementia with Lewy bodies: Skin nerve α-synuclein deposits. Neurology.2017;89(4):318-326. doi:10.1212/WNL.0000000000004146
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Donadio V, Incensi A, Piccinini C, et al. Skin nerve misfolded α-synuclein in pure autonomic failure and Parkinson disease. Ann Neurol. 2015;79(2):306-316. doi:10.1002/ana.24567
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Donadio V, Incensi A, Cortelli P, et al. Skin sympathetic fiber α-synuclein deposits: a potential biomarker for pure autonomic failure. Neurology 2013;80(8):725-732. doi: 10.1212/WNL.0b013e3182825127
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Doppler K, Antelmi E, Kuzkina A, et al. Consistent skin α-synuclein positivity in REM sleep behavior disorder – A two center two-to-four-year follow-up study. Parkinsonism Relat Disord. 2021;86:108-113. doi: 10.1016/j.parkreldis.2021.04.007
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Doppler K, Weis J, Karl K, et al. Distinctive distribution of phospho-alpha-synuclein in dermal nerves in multiple system atrophy. Mov Disord. 2015;30(12):1688-92. doi: 10.1002/mds.26293
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Freeman R, Gonzalez-Duarte A, Barroso F, et al. Cutaneous amyloid is a biomarker in early ATTRv neuropathy and progresses across disease stages. Ann Clin Transl Neurol. 2022, 9(9), 1370–1383. doi: 10.1002/acn3.51636
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Gainnoccaro MP, Avoni P, Rizzo G, et al. Presence of skin α-synuclein deposits discriminates Parkinson’s disease from progressive supranuclear palsy and corticobasal syndrome. J Parkinson’s Dis. 2022; 12(2): 585-591. doi: 10.3233/JPD-212904
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Gibbons CH, Levine T, Adler C, et al. Skin biopsy detection of phosphorylated α-synuclein in patients with synucleinopathies. JAMA.2024;331(15):1298–1306. doi:10.1001/jama.2024.0792
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Gibbons C, Wang N, Rajan S, et al. Cutaneous α-synuclein signatures in patients with multiple system atrophy and Parkinson disease. Neurology.2023; 100(15), e1529–e1539. doi: 10.1212/WNL.0000000000206772
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Gibbons CH, Wang N, Freeman R. Cutaneous alpha-synuclein from paraffin embedded autopsy specimens in Parkinson’s disease. J Parkinsons Dis.2017;7(3):503-509. doi:10.3233/JPD-171088
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Gibbons CH, Garcia J, Wang N, Shih LC, Freeman R. The diagnostic discrimination of cutaneous α-synuclein deposition in Parkinson disease. Neurology.2016;87(5):505-512. doi:10.1212/WNL.0000000000002919
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Kim JY, Illigens BM, McCormick MP, Wang N, Gibbons CH. Alpha-synuclein in skin nerve fibers as a biomarker for alpha-synucleinopathies. J Clin Neurol.2019;15(2):135-142. doi:10.3988/jcn.2019.15.2.135
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Lauria G, Bakkers M, Schmitz C, et al. Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study. J Peripher Nerv Syst. 2010;15(3):202-207. doi:10.1111/j.1529-8027.2010.00271.x
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Lauria G, Hsieh ST, Johansson O, et al. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. Eur J Neurol. 2010;17(7):903-12, e44-9. doi:10.1111/j.1468-1331.2010.03023.x
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Miglis MG, Zitser J, Schneider L, et al. Cutaneous α-synuclein is correlated with autonomic impairment in isolated rapid eye movement sleep behavior disorder. Sleep. 2021;44(12):zsab172. doi:10.1093/sleep/zsab172
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Niemann N, Billnitzer A, Jankovic, J. Parkinson’s disease and skin. Parkinsonism Relat Disord. 2021; 82; 61-76. doi:10.1016/j.parkreldis.2020.11.017
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Provitera V, Gibbons CH, Wendelschafer-Crabb G, et al. The role of skin biopsy in differentiating small-fiber neuropathy from ganglionopathy [published correction appears in Eur J Neurol. 2019 Jan;26(1):202]. Eur J Neurol. 2018;25(6):848-853. doi:10.1111/ene.13608
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Provitera V, Gibbons CH, Wendelschafer-Crabb G, et al. A multi-center, multinational age- and gender-adjusted normative dataset for immunofluorescent intraepidermal nerve fiber density at the distal leg. Eur J Neurol. 2016;23(2):333-338. doi:10.1111/ene.12842
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Wang N, Gibbons CH, Lafo J, Freeman R. α-synuclein in cutaneous autonomic nerves. Neurology. 2013;81(18):1604-1610. doi:10.1212/WNL.0b013e3182a9f449
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